Anything I design is designed to work in IE. It may not work AS WELL as it would in later versions or on Firefox if you're using IE6 - but it's usable.
In general, web development is now completely shunning IE6 - or at least starting to. In general, MOST IE users now run 7. There's something like 10% still running 6 - quite a lot considering the massive built-in audience IE has, but to be fair, most of those are big businesses or schools that are just ridiculously slow at keeping up-to-date in any shape or form. And aside from maybe the schools, our audience isn't THAT likely to be effected.
Overall, we have a pretty high FireFox to IE ratio on Pokecharms - probably one of the higher you'll find online at all - something like 55:45. It's a lot harder to get a read on how many of those IE users are using IE6, but it's safe to say it's probably pretty minimal.
So, yeah, if you're running a crap browser, websites look crap - so if it's your computer, upgrade already. If it's not, get a petition together to your systems admin to get off his lazy arse and actually do something.