I mentioned this game in a previous topic, but Rise of the Triad > every other game in existence when it comes to weapons. While some of the weapons, mainly the pistol, machine gun and bazooka are fairly bog-standard, later levels start to bring in weapons on par with Doom's BFG9000 in terms of power.
The Drunk Missile is the first of such silly weapons encountered in the game. The thing sprays about 5-6 homing missiles out at once per shot, effectively obliterating every enemy the missiles manage to sniff out (usually everyone on the screen.) It's the easiest "superweapon" to use in RotT, minus the last one which I'll get to later. Just to make the Drunk Missile even nastier, its fire rate is abnormally high for a rocket launcher; it fires almost as fast as most pistols in today's FPS games, which is brutal given that the thing is belching out at least 5 homing missiles per shot.
The Firebomb is quite difficult to use effectively since the blast radius of the missile is so wide it's very easy to get caught in your own missile blast, which unfortunately means instant death for you if you aren't careful. The weapon fires out a single missile per shot which generates a massive, cross-shaped fire blast upon contact with an object, living or otherwise. If the missile itself doesn't get the kill, the fire blast certainly will do since it does significantly more damage than the missile itself, and the flames are large enough to annihilate, once again, an entire screen's worth of enemies in a single shot.
The Flamewall is exactly what it says on the tin. It fires a missile that, unlike most, doesn't inflict splash damage to the wielder if they aim it directly at the floor. What it does do is unleash an enormous, fast-moving wall of flames that incinerates every enemy in its path, complete with a comedic xylophone sound effect as their charred skeletons crumble to the ground. Again, got an entire army of enemies charging towards you? One shot from this thing will kill them all. The weapon's only weakness is that it only unleashes the flame wall if it hits the floor - if the missile hits a wall or even an enemy, it simply explodes with no more effect than a regular bazooka missile. Fortunately, this issue can be avoided by simply aiming the thing directly at the floor (as mentioned earlier) and firing it directly in front of your character's feet.
The best weapon in this game, and the best weapon I've ever seen in a video game (ever) is Godfire. If you thought wiping out an entire screen of enemies was good enough, Godfire makes even that seem like nothing. Not only does it kill all the enemies on the screen with a single hit, but also kills all the other enemies it can sniff out in the room too. The homing ability is so strong that even if it's pointed and fired in the complete opposite direction to your enemies, the blast will immediately pass right through you and obliterate everyone behind you. A blind man could beat the entire game with this weapon, no exaggeration...because not only does it have infinite ammunition, it also makes the wielder completely invulnerable to damage. Now, of course there has to be a catch for such an overpowered weapon, and there is: the weapon will disappear after two minutes once picked up, although there is a cheat code that lets you use it permanently (surprise surprise.) Best weapon in gaming ever - it's as close to an I-Win Button as a weapon can get without actually being one.
Unreal Tournament's Redeemer gets a honorary mention, and for anyone that's played UT, you'll know exactly why.